[Intraosseous metastasis of malignant tumors (microangiographic study)]

The vascular factor in intraosseous metastasizing of malignant tumors has been studied insufficiently. The present study consisted in intravital microangiography of random bred albino rats after intraosseous implantation of sarcoma-45. Tumor development resulted in destructive changes in the zone of implantation and then in metastasis to the proximal metaphysis of a bone. Intraosseous tumor cell transfer was noted in the venous blood stream; tumor development beyond the bone occurred in the haversian and Volkmann's canals. It has been established that local readjustment of the blood vessels and three-zonal rearrangement of the blood circulation in the zone of implantation play a major role in the mechanism of intraosseous metastasis of malignant tumors.