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Updated: Nov 12, 2025

Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Physiologic Mechanisms of Weight Loss Following Metabolic/Bariatric Surgery
1Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Thorn 1503, Boston, MA 02115, USA. Electronic address: https://twitter.com/JamesNLuo.
Abstract:
Bariatric and metabolic surgery has evolved from simple experimental procedures for a chronic problem associated with significant morbidity into a sophisticated multidisciplinary treatment modality rooted in biology and physiology. Although the complete mechanistic narrative of bariatric surgery cannot yet be written, significant advance in knowledge has been made in the past 2 decades. This article provides a brief overview of the most studied hypotheses and their supporting evidence. Ongoing research, especially in frontier areas, such as the microbiome, will continue to refine, and perhaps even revise, current mechanistic understanding.
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