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Updated: Nov 12, 2025

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Factor V Deficiency (Owren's Disease) in a Patient at High Risk for Transfusion-Associated Circulatory Overload and

Michael G Fitzsimons1, Conor Barrett2, Scott Streckenbach1

  • 1Harvard Medical School, Boston, MA; Division of Cardiac Anesthesia, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA.

Journal of Cardiothoracic and Vascular Anesthesia
|March 21, 2021
PubMed

Congenital factor V deficiency is an extremely rare abnormality and may be associated with significant bleeding as a result of trauma or surgery. Perioperative management primarily includes the administration of fresh frozen plasma to replace the deficient clotting factor. Acute administration of multiple blood products is a risk factor for transfusion-associated circulatory overload. Herein, the case of a 71-year-old man with an ejection fraction of 13% and a history of congenital factor V deficiency who was at risk for significant bleeding and transfusion-associated circulatory overload who underwent successful complex extraction of a right atrial pacing lead is reported.

Keywords:
bleedingcoagulopathy, factor Velectrophysiology

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