Development of a pharmacoeconomic registry: an example using hormonal contraceptives

Area of Science:

• Health Economics
• Pharmacoeconomics
• Outcomes Research

Background:

• Existing registries for economic evaluations are limited by the types of studies they include.
• There is a need for intervention-specific registries that capture diverse economic evaluations and quality of life data.
• Disease-specific registries can guide researchers in evaluating literature and conducting future economic analyses.

Purpose of the Study:

• To describe the development of a pharmacoeconomic registry.
• To provide best practices for registry development using hormonal contraceptives as an example.
• To create a comprehensive database of economic evaluations and associated data.

Main Methods:

• An expert panel defined the registry's clinical focus and key variables.
• A web-based tool was designed for data collection and storage.
• Literature searches, article screening, and data extraction were performed, with expert input throughout.

Main Results:

• The registry includes 65 articles on hormonal contraceptives, covering various economic evaluation types (cost-effectiveness, cost-utility, cost-benefit, cost-minimization, cost analyses, cost of illness) and quality of life studies.
• Best practices for registry development were summarized as recommendations.
• The registry, data dictionary, and data files are available in supplementary information.

Conclusions:

• The developed registry serves as a comprehensive database for economic evaluations, including costs, clinical probabilities, and health-state utility estimates.
• Data from this registry can identify literature trends, support systematic reviews and meta-analyses, and inform novel pharmacoeconomic model development.