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Updated: Jul 30, 2026
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Neonatal coning secondary to hypoxic ischaemic encephalopathy: A case study and literature review
Yasser Soliman1, Kamran Yusuf2, Marc Blayney3
1Division of Neonatology, Department of Pediatrics, Hospital for Sick Children, School of Medicine, University of Toronto, Toronto, Ontario.
Introduction:
Brain herniation is an extremely rare complication of hypoxic ischaemic encephalopathy (HIE) in the neonatal period with only a single report described. We report a 2-day-old term infant with severe HIE, who developed diffuse brain oedema and herniation.
Case Presentation And Description:
A term female infant delivered by vacuum, required therapeutic hypothermia for severe encephalopathy. At 36 hours of age, a marked change in neurological status was noted with signs of brainstem involvement. A head Computed Tomography Scan showed uncal and tonsillar herniation.
Conclusion:
Vigilance in monitoring neonatal neurological status during therapeutic hypothermia is imperative for early brain herniation detection.
