Related Experiment Video
Updated: Nov 12, 2025
07:30
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
3.2K
Cerebral blood flow changes during aging process and in cognitive disorders: A review
Naghmeh Mokhber1,2, Aidin Shariatzadeh3, Abolfazl Avan4
1Department of Psychiatry, Western University, Canada.
The Neuroradiology Journal
|March 22, 2021
Summary
Cerebral blood flow (CBF) changes are linked to normal aging and cognitive disorders like Alzheimer's disease. Measuring CBF may aid in early detection and understanding the causes of cognitive decline.
Area of Science:
- Neuroscience
- Gerontology
- Medical Imaging
Background:
- Cerebral blood flow (CBF) assessment is crucial for understanding brain health.
- Cognitive disorders, including normal aging, vascular cognitive impairment (VCI), and Alzheimer's disease (AD), are associated with alterations in brain function.
- Existing research highlights the need for a comprehensive summary of CBF changes in these conditions.
Purpose of the Study:
- To summarize the evidence on cerebral blood flow (CBF) changes in normal aging and common cognitive disorders.
- To review the historical development of CBF assessment techniques.
- To explore the association between CBF and cognitive status in aging, VCI, and AD.
Main Methods:
- A systematic literature search was conducted on PubMed for studies on CBF changes.
- Studies published up to January 1, 2019, were included.
- Evidence was summarized, focusing on normal aging, VCI, and AD.
Main Results:
- CBF studies show promise in cognition research.
- Age-related CBF changes may stem from neuronal loss or reduced neuronal activity.
- CBF reduction might precede cognitive decline in VCI and AD.
Conclusions:
- CBF measurement is a valuable tool for cognitive research.
- Understanding CBF alterations can contribute to the early detection of cognitive disorders.
- CBF research aids in elucidating the underlying etiology of cognitive impairment.
Related Concept Videos
01:30Cognitive Development During Adulthood
472
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
472
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
72
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
72
01:26Aging
405
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
405
01:15Drug Dosing: Geriatric Patients
77
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
77
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
68
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
68
01:26Alzheimer's Disease: Overview
1.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.0K