Related Experiment Video
Updated: Nov 12, 2025
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Cognition in acute relapses: A psychometric evaluation and its correlation with event-related potential, P300 in
Muhtesem Gedizlioglu1, Asli Koskderelioglu2, Melike Vural3
1Department of Neurology, Atakalp Private Heart Hospital, Izmir, Turkey.
Objective:
During acute relapses of multiple sclerosis (MS), physical symptoms attract utmost care. However, cognitive impairment may constitute an substantial part of a new relapse. In this study, we evaluated the cognitive status of MS patients during acute relapses.
Materials And Methods:
We enrolled 35 definite MS patients and 21 healthy subjects. Neuropsychometric tests and the event-related potential, P300 were administered to the MS patients before corticosteroid treatment, and 3 months later. The control subjects were tested only once.
Results:
The differences between the scores of the Timed 25-Foot Walk test, the Brief Repeatable Battery subtests (10/36 SPART, SDMT, SRT, SRT-LTM) in the relapse and remission phases were statistically significant (p = .005, p = .007, p = .05, p = .029, p = .001, respectively). The latencies of P300 waves during the relapses were significantly prolonged than the ones in the remission and the controls' (p = .004, p < .001, respectively).
Conclusions:
In this study, we observed a significant involvement of visual-spatial perception, remote memory, and recall, as well as P300 latencies in acute relapses. The inclusion of cognitive assessment during a relapse can provide accurate information on cognitive status for future treatment modalities.
Insights
Cognitive impairment is common during multiple sclerosis (MS) relapses. This study found significant deficits in memory and visual-spatial skills, along with prolonged P300 event-related potentials during MS relapses.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Multiple sclerosis (MS) relapses often present with physical symptoms, but cognitive impairment can also be a significant component.
- Assessing cognitive status during acute MS relapses is crucial for comprehensive patient care.
Purpose of the Study:
- To evaluate the cognitive status of patients with multiple sclerosis during acute relapses.
- To investigate the impact of relapses on cognitive functions and event-related potentials.
Main Methods:
- 35 definite MS patients and 21 healthy controls were enrolled.
- Neuropsychometric tests and P300 event-related potentials were administered to MS patients before and after treatment, and to controls once.
- Cognitive tests included Timed 25-Foot Walk, Brief Repeatable Battery subtests (10/36 SPART, SDMT, SRT, SRT-LTM).
Main Results:
- Statistically significant differences were observed in cognitive test scores between relapse and remission phases in MS patients (p < 0.05).
- P300 wave latencies were significantly prolonged during MS relapses compared to remission and control groups (p < 0.005).
Conclusions:
- Acute MS relapses are associated with significant impairments in visual-spatial perception, remote memory, and recall.
- Cognitive assessments during MS relapses are vital for accurate evaluation and guiding future treatment strategies.
More Related Videos
11:39Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique
Published on: September 7, 2022
08:26Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy
Published on: January 11, 2016