Recent Advances in Chalcone-Based Anticancer Heterocycles: A Structural and Molecular Target Perspective

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Organic Chemistry

Background:

• Chalcones are versatile compounds with significant biological activities.
• They have demonstrated potent anticancer properties through various mechanisms.
• Research interest in chalcones for health benefits is continuously growing.

Purpose of the Study:

• To review the impact of structural variations on the anticancer efficacy of chalcone hybrids.
• To elucidate the mechanisms of action and molecular targets of these compounds.
• To assess their potential in advancing cancer chemotherapy.

Main Methods:

• Literature review of studies published in 2018-2019.
• Analysis of structure-activity relationships (SAR) of chalcone hybrids.
• Compilation of data on molecular targets and biological activities.

Main Results:

• Chalcone hybrids show significant anticancer activity by targeting key molecules like ABCG2, AR, HDAC, and VEGF.
• Structural modifications significantly influence anticancer potency and selectivity.
• Understanding mechanisms of action aids in designing more effective anticancer agents.

Conclusions:

• Chalcone hybrids represent a promising scaffold for developing novel anticancer therapeutics.
• Further research into their mechanisms and SAR can optimize drug design.
• These compounds hold potential for future cancer chemotherapy strategies.