A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis

Area of Science:

• Biochemistry
• Pathology
• Proteomics

Background:

• Amyloidosis results from extracellular protein deposition, with 36 known amyloidogenic proteins in humans.
• Accurate identification of the specific amyloid protein is vital for effective patient therapy.
• Apolipoprotein A-IV is recognized as amyloid-associated, yet apolipoprotein A-IV amyloidosis is infrequently reported.

Observation:

• This study presents a case of systemic apolipoprotein A-IV-associated amyloidosis.
• The diagnosis was confirmed through proteome analysis of formalin-fixed paraffin-embedded tissue.
• Immunohistochemical techniques further supported the identification of apolipoprotein A-IV as the causative protein.

Findings:

• Proteome analysis successfully identified apolipoprotein A-IV in amyloid deposits.
• Formalin-fixed paraffin-embedded tissue was effectively utilized for proteomic and immunohistochemical analysis.
• This case expands the understanding of apolipoprotein A-IV amyloidosis.

Implications:

• The findings highlight the utility of proteome analysis in diagnosing rare amyloidosis subtypes.
• This diagnostic approach can guide therapeutic strategies for patients with specific amyloid protein types.
• Further research into apolipoprotein A-IV amyloidosis is warranted to understand its pathogenesis and clinical course.