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Updated: Nov 11, 2025

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics
Amir Ajoolabady1,2, Hamid Aslkhodapasandhokmabad3, Nils Henninger4,5
1Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Many neurodegenerative diseases are associated with pathological aggregation of proteins in neurons. Autophagy is a natural self-cannibalization process that can act as a powerful mechanism to remove aged and damaged organelles as well as protein aggregates. It has been shown that promoting autophagy can attenuate or delay neurodegeneration by removing protein aggregates. In this paper, we will review the role of autophagy in Alzheimer's disease (AD), Parkinson's Disease (PD), and Huntington's Disease (HD) and discuss opportunities and challenges of targeting autophagy as a potential therapeutic avenue for treatment of these common neurodegenerative diseases.
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