Related Experiment Video
Updated: Nov 11, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Acute Kidney Injury in Cardiac Surgery
Christina Massoth1, Alexander Zarbock1, Melanie Meersch1
1Department of Anesthesiology, Intensive Care, and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, A1, Münster 48149, Germany.
Abstract:
Acute kidney injury (AKI) occurs frequently after cardiac surgery and is associated with high morbidity and mortality. Although the number of cardiac surgical procedures is constantly growing worldwide, incidence of cardiac surgery-associated AKI is still around 40% and has a significant impact on global health care costs. Numerous trials attempted to identify strategies to prevent AKI and attenuate its detrimental consequences. Effective options remained elusive. Current evidence supports a multimodal risk-stratification approach with biomarker-guided management of high-risk patients, perioperative administration of dexmedetomidine, and implementation of a care bundle as recommended by the Kidney Disease: Improving Global Outcomes group.
Related Concept Videos
Cardiac Catheterization I: Pre-Procedure Overview
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology

