Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.1K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

820
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
820
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fractionated high-dose vitamin c sustains higher plasma trough concentrations in advanced solid tumors: a phase I clinical study.

Translational oncology·2026
Same author

Leveraging Lithium-Bond Chemistry in a Tailored Electrolyte to Control Sulfur and Lithium Evolution in Li-S Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Harnessing CRISPR-Cas12 and Microfluidics Chips for Multiplex Respiratory Pathogens Diagnosis.

ACS sensors·2026
Same author

Spatial transcriptomic-metabolic features of tumor foci and tumor capsule in microvascular invasion with hepatocellular carcinoma: A spatial multi-omics study.

PLoS medicine·2026
Same author

Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma.

Cell reports. Medicine·2026
Same author

Metacognitive sensitivity predicts the quality of information search in value-based decision making.

Cognition·2025
Same journal

Plant-Plant Communication for Systemic Acquired Resistance under Biotic Stress Spatiotemporally Tracked by an <i>In Situ</i> Surface-Enhanced Raman Spectroscopy Aerosol Spraying Analyzer.

ACS sensors·2026
Same journal

Modulating Electronic Structure via Bimetallic D<i>-</i>Band Engineering toward an Ultrasensitive Sensor Platform for Caffeic Acid in Food.

ACS sensors·2026
Same journal

Indiscriminate <i>T</i><i>rans</i>-Cleavage Activity of CRISPR/SuCas12a2 Enables Sensitive Detection of SARS-CoV-2.

ACS sensors·2026
Same journal

Spin-State Engineering in 2D Metal-Organic Frameworks for Ultrasensitive Room-Temperature Ammonia Sensing.

ACS sensors·2026
Same journal

A Wearable Microneedle-Based Electrochemical Aptamer Sensor: Enabling Real-Time Dynamic NT-proBNP Monitoring for Enhanced Heart Failure Management.

ACS sensors·2026
Same journal

Double-Strand Gated Biosensor for Ultrasensitive T4 PNK Detection via λ-Exonuclease-Driven Background Suppression and Dimer G-Triplex Signal Amplification.

ACS sensors·2026
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.6K

Aptamer-Exosomes for Tumor Theranostics.

Kezhen Yi1, Yuan Rong1, Lanxiang Huang1

  • 1Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, P.R. China.

ACS Sensors
|March 23, 2021
PubMed
Summary
This summary is machine-generated.

Exosomes, tiny vesicles carrying biomolecules, show promise as cancer biomarkers due to their changing contents. Combining exosomes with aptamers offers new avenues for precise cancer diagnosis and personalized treatment.

Keywords:
SELEXaptamerbiosensorexosomemicrofluidic chippersonalized treatmentprecise diagnosistumor theranostics

More Related Videos

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.6K
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

401

Related Experiment Videos

Last Updated: Nov 11, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.6K
Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.6K
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

401

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Exosomes are crucial intercellular communicators, transporting biomolecules like proteins, nucleic acids, and lipids.
  • Exosome morphology remains consistent across diseases, but their content varies, making them valuable biomarker sources.
  • Exosomes function as natural delivery vehicles, protecting cargo and facilitating cellular uptake.

Purpose of the Study:

  • To explore the applications of exosomes and aptamers in cancer research.
  • To analyze the synergistic potential of combining aptamers with exosomes for cancer diagnosis and therapy.
  • To propose future directions for aptamer-exosome technology in personalized cancer medicine.

Main Methods:

  • Literature review and analysis of exosome and aptamer applications in cancer.
  • Investigating the characteristics of exosomes as biomarker sources and drug delivery vehicles.
  • Examining the development and potential of aptamer-exosome conjugates.

Main Results:

  • Exosomes are recognized as promising biomarkers for tumor diagnosis and prognosis due to their disease-specific cargo.
  • Genetically engineered exosomes, particularly when combined with aptamers, can serve as effective therapeutic delivery systems.
  • Aptamers offer high binding affinity and specificity, enhancing exosome-based targeting and detection.

Conclusions:

  • The combination of aptamers and exosomes, termed "aptamer-exosomes," represents a novel frontier in cancer research.
  • Aptamer-exosomes hold significant potential for precise cancer diagnosis and personalized therapeutic strategies.
  • Further research into aptamer-exosome technology is crucial for advancing cancer treatment and management.