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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
A Wearable Microneedle-Based Electrochemical Aptamer Sensor: Enabling Real-Time Dynamic NT-proBNP Monitoring for
Tianyi Chen1, Gandong Zhou2,3,4, Lihao Guo2,3
1Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
ACS Sensors
|July 3, 2026
Summary
A novel wearable microneedle sensor offers real-time monitoring of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. This innovation promises faster heart failure (HF) management by overcoming delays associated with traditional lab tests.
Area of Science:
- Biomedical Engineering
- Cardiovascular Diagnostics
- Biosensor Technology
Background:
- Heart failure (HF) is a critical condition with high incidence and mortality.
- Monitoring N-terminal pro-B-type natriuretic peptide (NT-proBNP) is crucial for HF prediction and management.
- Current NT-proBNP testing methods face delays due to centralized laboratory analysis.
Purpose of the Study:
- To develop a wearable microneedle-based electrochemical aptasensor (MEAS) for real-time NT-proBNP detection.
- To enable dynamic data analysis and wireless readout of NT-proBNP levels via smartphone integration.
- To provide a timely and patient-centered alternative to conventional diagnostic methods.
Main Methods:
- Fabrication of a microneedle-based electrochemical aptasensor for NT-proBNP detection.
- Integration of real-time signal processing and Bluetooth wireless communication.
- In vitro characterization of analytical performance (linearity, detection limit, selectivity, stability).
- In vivo testing for NT-proBNP monitoring and comparison with ELISA.
Main Results:
- The MEAS demonstrated a wide linear range (10-2000 pg/mL) and a low detection limit (8.61 pg/mL).
- The sensor exhibited excellent selectivity against common interferents and stable performance over repeated measurements.
- In vivo studies showed reliable NT-proBNP monitoring with good agreement compared to ELISA, alongside favorable biosafety.
Conclusions:
- The developed microneedle aptasensor offers a promising alternative for NT-proBNP monitoring.
- This technology facilitates real-time, patient-centered data acquisition, advancing heart failure management.
- The wearable sensor overcomes limitations of conventional testing, enabling quicker clinical decisions.
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