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Transcranial MR-Guided Histotripsy System.

Ning Lu, Timothy L Hall, Dave Choi

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |March 23, 2021
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    Summary
    This summary is machine-generated.

    This study developed a transcranial MR-guided histotripsy system for in vivo brain treatment. The system successfully treated pig brains through a human skull, demonstrating feasibility for future applications.

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    Area of Science:

    • Neurosurgery
    • Medical Imaging
    • Acoustic Therapy

    Background:

    • Histotripsy shows promise for non-invasive tissue ablation.
    • Transcranial treatments require overcoming skull-induced acoustic aberrations.

    Purpose of the Study:

    • To develop and characterize a transcranial MR-guided histotripsy (tcMRgHt) system.
    • To evaluate the system's feasibility for in vivo brain treatment through an excised human skull.

    Main Methods:

    • Designed and fabricated a 700-kHz, 128-element MR-compatible phased-array ultrasound transducer.
    • Acoustically characterized the system, assessing pressure, steering range, and MR compatibility.
    • Validated transcranial treatment in phantoms and in vivo pig brains using electronic focal steering.

    Main Results:

    • Achieved peak negative pressures of up to 72 MPa through an excised human skull with aberration correction.
    • Demonstrated electronic focal steering capabilities for precise targeting.
    • Successfully treated targeted cerebral tissue in pigs, confirmed by MRI, without significant adverse effects.

    Conclusions:

    • The developed tcMRgHt system is feasible for in vivo transcranial treatment.
    • This preclinical system shows potential for non-invasive therapeutic applications in the brain.
    • Further research can advance MR-guided histotripsy for clinical neurosurgery.