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Addressing Full-Thickness Skin Defects: A Review of Clinically Available Autologous Skin Replacements.
Stephen Milner1, Edward Swanson1, Mark Granick2
1Department of Research and Development, PolarityTE, Salt Lake City, Utah.
Surgical Technology International
|March 23, 2021
Summary
Clinically available autologous skin replacements aim to restore full-thickness skin defects. The goal is to regenerate a functional skin organ, not just resurface the defect.
Area of Science:
- Regenerative Medicine
- Tissue Engineering
- Dermatology
Background:
- Full-thickness skin defects pose significant clinical challenges.
- Current treatments focus on skin resurfacing, often neglecting full functional restoration.
- Skin is a complex organ vital for immune, nervous, and endocrine functions.
Purpose of the Study:
- To review clinically available autologous skin replacements.
- To emphasize the need for physiologically functional skin regeneration.
- To highlight advancements in treating full-thickness skin defects.
Main Methods:
- Review of literature on autologous keratinocyte cultures.
- Analysis of treatments combining scaffolds, diverse cell types, macromolecules, and growth factors.
- Evaluation of current autologous skin replacement strategies.
Main Results:
- Autologous keratinocyte culture and combination therapies aid in resurfacing skin defects.
- Existing treatments vary in their ability to restore full skin function.
- Regenerating a physiologically active skin organ remains a key objective.
Conclusions:
- Autologous skin replacements are crucial for treating full-thickness defects.
- Restoring skin's role as a dynamic biological factory is paramount.
- Future strategies must prioritize comprehensive skin organ regeneration for optimal patient outcomes.
