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Related Experiment Videos

Light-addressable potentiometric sensor for biochemical systems.

D G Hafeman1, J W Parce, H M McConnell

  • 1Molecular Devices Corporation, Palo Alto, CA 94304.

Science (New York, N.Y.)
|May 27, 1988
PubMed
Summary
This summary is machine-generated.

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This study introduces a sensitive method for measuring biochemical reactions using an electrolyte-insulator-semiconductor device. The technology allows for the detection of multiple chemical events on a single semiconductor chip.

Area of Science:

  • Biochemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Potentiometric measurements are crucial for analyzing biochemical reactions.
  • Existing methods for measuring potential changes can be limited in sensitivity and scope.

Purpose of the Study:

  • To develop a highly sensitive method for potentiometric measurement of biochemical reactions.
  • To demonstrate the capability of a single semiconductor device for analyzing multiple chemical events.

Main Methods:

  • Utilizing an alternating photocurrent through an electrolyte-insulator-semiconductor interface.
  • Employing a spatially selectable photoresponse for localized detection.

Main Results:

  • The electrolyte-insulator-semiconductor interface demonstrated high sensitivity in measuring potential changes.

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  • A single semiconductor device was capable of determining multiple chemical events simultaneously.

    • Conclusions:

    • Alternating photocurrent measurements offer a sensitive approach for potentiometric analysis of biochemical reactions.
    • Spatially selectable photoresponse in semiconductor devices enables multiplexed chemical event determination.