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The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease

Yan Chen1, Yan-Xia Chen1, Chong Huang1

  • 1Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, People's Republic of China.

International Journal of General Medicine
|March 24, 2021
PubMed

Insights

Serum Klotho and FGF23 levels are linked to cardiac valve calcification in chronic kidney disease (CKD) patients. Lower Glomerular Filtration Rate (GFR) correlates with increased FGF23 and decreased Klotho, both identified as independent risk factors.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Cardiac valve calcification is a common complication in patients with chronic kidney disease (CKD).
  • The roles of serum Klotho and Fibroblast Growth Factor 23 (FGF23) in this process are not fully understood.

Purpose of the Study:

  • To investigate the clinical significance of serum Klotho and FGF23 in predicting cardiac valve calcification among patients with varying stages of CKD.
  • To identify independent risk factors for cardiac valve calcification in this population.

Main Methods:

  • 180 patients with CKD were categorized into three groups based on disease stage (CKD2~3, CKD4, CKD5).
  • Cardiac valve calcification was assessed using ultrasound.
  • Logistic regression analysis was employed to determine independent risk factors.

Main Results:

  • Serum FGF23 levels were inversely correlated with Glomerular Filtration Rate (GFR), increasing as GFR decreased.
  • Serum Klotho levels showed a positive correlation with GFR, decreasing as GFR declined.
  • Logistic regression identified GFR, serum creatinine, FGF23, and Klotho as independent risk factors for cardiac valve calcification.

Conclusions:

  • Serum FGF23 and Klotho levels are significantly altered in CKD patients and are associated with cardiac valve calcification.
  • GFR, serum creatinine, FGF23, and Klotho are key independent risk factors for cardiac valve calcification in CKD.
  • These findings highlight the potential of FGF23 and Klotho as biomarkers for cardiovascular complications in CKD.
Abstract

Keywords:
FGF23Klothocardiac valve calcificationchronic kidney diseaselogistic regression analysis

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