[The effect of various caries preventive agents on the microflora of albino rats]

An experiment with 80 Wistar rats was performed to study, using cultural methods, the effect of locally and internally applied caries-preventive agents on the microbiological situation in the oral cavity and on the surface of the skin. Especially in case of combined internal and local application, fluoride-containing preparations exerted an inhibitory effect on the oral microflora that had been altered by a cariogenic diet and on the bacterial invasion of the skin. The influence of a locally applied mineral solution on bacterial growth was only insignificant.