HIF‑1α in myocardial ischemia‑reperfusion injury (Review)

Area of Science:

• Cardiovascular Biology
• Molecular Medicine
• Oxygen Homeostasis

Background:

• Myocardial ischemia-reperfusion injury (MIRI) is a critical clinical challenge with no current effective treatments.
• Understanding oxygen homeostasis has been advanced by studies on hypoxia and hypoxia-inducible factor-1α (HIF-1α).
• HIF-1α is a crucial transcription factor mediating adaptive responses to hypoxia and significantly impacts MIRI.

Purpose of the Study:

• To review the multifaceted roles and mechanisms of HIF-1α in the context of MIRI.
• To summarize current and emerging therapeutic interventions targeting HIF-1α for MIRI.
• To provide evidence supporting HIF-1α activation as a viable therapeutic strategy for MIRI.

Main Methods:

• Literature review focusing on hypoxia, HIF-1α, and MIRI.
• Analysis of studies detailing HIF-1α's molecular functions in MIRI.
• Compilation of data on HIF-1α-associated MIRI interventions.

Main Results:

• HIF-1α enhances mitochondrial function and reduces oxidative stress in MIRI.
• HIF-1α activates cardioprotective signaling pathways and downstream genes.
• HIF-1α interacts with non-coding RNAs, influencing MIRI pathogenesis.

Conclusions:

• HIF-1α activation demonstrates significant protective effects in MIRI.
• Interventions like natural compounds, exosomes, and conditioning techniques targeting HIF-1α show therapeutic potential.
• HIF-1α represents a promising therapeutic target for mitigating MIRI.