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Related Experiment Videos

Experimental nitrous oxide exposure as a model system for evaluating neurobehavioral tests.

F C Mahoney1, P A Moore, E L Baker

  • 1Harvard School of Public Health, Boston, MA 02115.

Toxicology
|May 1, 1988
PubMed
Summary

Nitrous oxide at 20% impaired psychomotor speed, while higher doses affected more cognitive functions. This study validates nitrous oxide as a model for neurobehavioral test evaluation.

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Previous research indicated 20% nitrous oxide impairs specific psychomotor speed tests.
  • Neurobehavioral functions like visuospatial ability, verbal learning, and mood were unaffected in prior studies.

Purpose of the Study:

  • To replicate and expand upon prior findings regarding nitrous oxide's neurobehavioral effects.
  • To assess reproducibility of earlier results with an additional anesthetic dose and a complex reaction time task.

Main Methods:

  • Fifteen male participants (24-34 years) underwent testing with the Neurobehavioral Evaluation System (NES).
  • Sessions included control, 20%, and 40% nitrous oxide doses, presented randomly after training.

Main Results:

  • The 20% dose impaired 2 of 3 psychomotor speed tests, with a third approaching significance (P=0.055).

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  • Complex reaction time was significantly affected at the 20% dose.
  • The 40% dose impaired 8 of 9 tests, with a ninth nearing significance (P=0.055).

    • Conclusions:

    • Results are consistent with previous studies, confirming dose-dependent neurobehavioral impairments.
    • Nitrous oxide is a valuable model for validating neurobehavioral tests due to its safety, ease of administration, and subject acceptance.