Multiparametric Quantitative MRI in Neurological Diseases.

Area of Science:

• Neuroimaging
• Biomedical Engineering
• Quantitative MRI

Background:

• Conventional MRI is limited to macroscopic pathology detection.
• Subtle microstructural tissue integrity impairments are often missed.
• Hardware and protocol variations complicate conventional MRI analysis.

Purpose of the Study:

• To review current multiparametric quantitative MRI (qMRI) techniques.
• To highlight key tissue parameters measurable by qMRI.
• To explore qMRI applications in neurological disease diagnosis and management.

Main Methods:

• Quantitative MRI (qMRI) parameter determination.
• Analysis of microstructural tissue processes.
• Review of qMRI applications in inflammatory, cerebrovascular, and neurodegenerative diseases.

Main Results:

• qMRI detects microstructural processes preceding tissue atrophy.
• It reveals early impairment of tissue integrity and disease-specific patterns.
• qMRI identifies damage in normal-appearing white matter and correlates with clinical symptoms.

Conclusions:

• Multiparametric qMRI provides valuable information beyond conventional MRI.
• It enables early diagnosis, monitoring of disease progression, and therapeutic evaluation.
• qMRI enhances characterization of neurological diseases by assessing microstructural integrity.