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Oral Pregabalin in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Xian-Xue Wang1, Jing Dai1, Xing-Guo Hu2
1Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.
Biomed Research International
|March 25, 2021
Summary
Pregabalin effectively reduces postoperative morphine use and hospital stay in cardiac surgery patients. This analgesic offers improved early recovery for patients undergoing these procedures.
Area of Science:
- Anesthesiology
- Pharmacology
- Cardiovascular Surgery
Background:
- Pregabalin is recognized for its analgesic properties.
- Cardiac surgery patients often experience significant postoperative pain.
- Evaluating pregabalin's efficacy in this population is clinically relevant.
Purpose of the Study:
- To systematically review and meta-analyze the effect of pregabalin on postoperative pain management in cardiac surgery.
- To assess pregabalin's impact on opioid consumption, extubation time, and hospital length of stay.
Main Methods:
- Searched PubMed, Embase, and Cochrane Library for eligible studies up to July 2020.
- Included seven trials with 463 patients.
- Analyzed total morphine consumption at 24 hours, intraoperative fentanyl, extubation time, and length of stay using random- or fixed-effects models.
Main Results:
- Pregabalin significantly reduced 24-hour morphine consumption (WMD: -5.44, P = 0.03).
- Patients receiving pregabalin had a significantly shorter hospital stay (WMD: -0.87, P = 0.002).
- No significant differences were found in intraoperative fentanyl consumption or extubation time.
Conclusions:
- Oral pregabalin is effective in reducing 24-hour morphine consumption post-cardiac surgery.
- Pregabalin administration is associated with a shorter hospital stay.
- The use of pregabalin appears to facilitate earlier postoperative recovery in cardiac surgery patients.
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