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Ultrastructural pathology in emetine-induced myopathy
L Halbig1, L Gutmann, H H Goebel
1Division of Neuropathology, University of Mainz, Federal Republic of Germany.
Acta Neuropathologica
|January 1, 1988
Summary
Anorexia nervosa patients consuming ipecac syrup developed progressive myopathy due to emetine hydrochloride. Muscle biopsies revealed sarcomere disruption and sarcotubular abnormalities, suggesting a reversible self-inflicted myopathy.
Area of Science:
- Neurology
- Toxicology
- Pathology
Background:
- Anorexia nervosa is an eating disorder often associated with purging behaviors.
- Ipecac syrup, containing emetine hydrochloride, has been used to induce vomiting in patients with eating disorders.
- Ipecac abuse can lead to toxic effects, including cardiac and muscular damage.