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Viime: Visualization and Integration of Metabolomics Experiments.

Roni Choudhury¹, Jon Beezley¹, Brandon Davis¹

¹Kitware Inc.

Journal of Open Source Software

|March 26, 2021

Summary

Metabolomics data integration is challenging due to diverse platform data structures. Viime, a web-based application, offers a solution for combining mass spectrometry and NMR data for comprehensive analysis.

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Area of Science:

Metabolomics
Systems Biology
Analytical Chemistry

Background:

Metabolomics provides a holistic biological readout influenced by genetics, lifestyle, and environment.
No single analytical platform offers complete metabolome coverage.
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) are common platforms, often used together.

Purpose of the Study:

To address the challenge of integrating metabolomics data from diverse platforms.
To present Viime, an open-source, web-based application for metabolomics data integration and visualization.

Main Methods:

Utilized mass spectrometry (MS) and nuclear magnetic resonance (NMR) data.
Developed Viime, a web-based application for data integration.
Employed visualization techniques to display integrated data.

Main Results:

Viime successfully integrates metabolomics data from multiple platforms.
The application handles diverse data structures and dynamic ranges from MS and NMR.
Facilitates observation of correlations between metabolites detected across different platforms.

Conclusions:

Viime overcomes challenges in integrating multi-platform metabolomics data.
Enables more comprehensive analysis by combining datasets.
Supports deeper insights into biological systems through integrated metabolomics data.