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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Mitogens and the Cell Cycle02:38

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: Nov 11, 2025

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

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Imatinib-induced eruptive nevi.

Lamiaa Hamie1, Rayah Touma Sawaya2, Ossama Abbas1

  • 1Department of Dermatology, American University of Beirut Medical Centre, Beirut, Lebanon.

Clinical and Experimental Pharmacology & Physiology
|March 26, 2021
PubMed
Summary
This summary is machine-generated.

Imatinib mesylate, a tyrosine kinase inhibitor, can cause skin side effects. This report details the first documented case of imatinib-induced eruptive nevi in a young patient with leukaemia.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Imatinib mesylate is a crucial tyrosine kinase inhibitor (TKI) for treating various cancers.
Keywords:
eruptive nevimelanocytic nevityrosine kinase inhibitors

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  • Cutaneous side effects are common with imatinib mesylate, including pigmentary changes.
  • Eruptive melanocytic nevi are known side effects of other TKIs but have not been previously linked to imatinib.