Recreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment

Nitrous oxide (N₂O), also known as "laughing gas," is a colorless, nonirritating gas. Clinically, it is widely used as an inhaled anesthetic, analgesic, and anxiolytic. In recent years, recreational abuse of N₂O has become increasingly common, especially among young adults and adolescents, but many of them lack awareness of the possible side effects associated with this drug. N₂O abuse can damage multiple systems, especially the nervous system, but the exact mechanism of N₂O toxicity remains controversial. At present, an increasing number of cases of nervous system damage caused by N₂O abuse have been reported both at home and abroad. Discontinuation of N₂O use and timely supplementation with vitamin B12 are essential for a good prognosis. Long-term abuse without timely treatment will eventually lead to irreversible neurological damage. In this article, we discuss the epidemiology of N₂O abuse, neurotoxicity mechanisms, clinical manifestations, relevant auxiliary examinations, treatments, and prognosis to improve social awareness of N₂O exposure risk, especially among users and clinicians.