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Published on: March 1, 2024
602
Association between psoriasis and dementia: A systematic review.
1Academy of Life Sciences, School of Medicine, Xi'an International University, Xi'an, China.
Neurologia
|March 27, 2021
Summary
Psoriasis, a chronic inflammatory disease, may increase dementia risk. Most studies reviewed suggest a link, but further research is needed to confirm this association and understand its nuances.
Area of Science:
- Dermatology
- Neurology
- Public Health
Background:
- Dementia risk factors include genetics, aging, environment, diseases, and lifestyle.
- Chronic systemic inflammation is a common phenotype in most dementia types.
- Psoriasis is a chronic systemic inflammatory disease, potentially linked to dementia risk.
Purpose of the Study:
- To systematically review existing literature on the association between psoriasis and dementia.
- To evaluate the evidence supporting psoriasis as a risk factor for dementia.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
- Quality assessment using the Newcastle-Ottawa Scale; 8 studies were reviewed.
Main Results:
- Six out of eight reviewed studies supported a positive association between psoriasis and increased dementia risk.
- One study indicated a decreased risk, while another found no significant association.
- Three studies were identified as having a higher risk of bias.
Conclusions:
- The majority of evidence suggests psoriasis may be a risk factor for dementia.
- Further high-quality, stratified cohort studies are necessary.
- Investigating psoriasis severity and treatment impact on dementia risk is crucial.
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