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Related Experiment Video

Updated: Nov 11, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

How strong is the link between periodontitis and stroke?

G Baniulyte¹, K Piela¹, S Culshaw²

¹Oral Sciences, Glasgow Dental Hospital and School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Evidence-Based Dentistry

|March 27, 2021

Summary

Individuals with periodontitis are twice as likely to suffer a stroke. This meta-analysis confirms a significant association between periodontal disease and increased stroke risk, highlighting the need for further research.

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Last Updated: Nov 11, 2025

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Area of Science:

Medical Research
Epidemiology
Cardiovascular Science

Background:

Periodontal disease is a chronic inflammatory condition affecting the gums and supporting structures of the teeth.
Cerebrovascular accidents (strokes) represent a significant global health burden.
Emerging evidence suggests a potential link between systemic inflammation and cardiovascular events.

Purpose of the Study:

To systematically review and meta-analyze observational studies investigating the association between periodontitis and the risk of cerebrovascular accidents (stroke).
To quantify the risk of stroke in individuals with periodontitis compared to those without.
To assess the heterogeneity and quality of included studies.

Main Methods:

A comprehensive literature search was conducted across multiple databases (PubMed, Scopus, Web of Science, etc.) up to September 2018.
Observational studies in humans examining the link between periodontitis and stroke risk were included.
Data were extracted and analyzed using meta-analysis techniques, calculating odds ratios (OR) and risk ratios (RR) with 95% confidence intervals.

Main Results:

Ten studies with a low risk of bias were included, involving a total of 80 to 15,792 participants.
Individuals with periodontitis were found to be twice as likely to suffer a stroke (OR 2.31) and specifically an ischaemic stroke (OR 2.72).
Cohort studies indicated a higher risk of stroke (RR 1.88) in individuals with periodontitis, with minimal heterogeneity observed.

Conclusions:

The meta-analysis provides strong evidence for an association between periodontal disease and an increased risk of stroke.
Further prospective studies are needed to explore the relationship between periodontal disease severity, stroke severity, and the impact of periodontal treatment on stroke outcomes and survival.