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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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The emerging role of circular RNAs in cardiovascular diseases

Yuejia Ding1, Chunmiao Lu1, Wanqin Zhang1

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Journal of Physiology and Biochemistry
|March 27, 2021
PubMed

Insights

Circular RNAs (circRNAs) are novel molecules increasingly linked to cardiovascular diseases (CVD). This review explores circRNA biogenesis, function, and their crucial role in CVD development and progression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a leading global cause of death.
  • Circular RNAs (circRNAs) are a newly identified class of noncoding RNA molecules.
  • Emerging research suggests a significant association between circRNAs and CVD.

Purpose of the Study:

  • To review the biogenesis and functions of circRNAs.
  • To elucidate the role of circRNAs in the pathogenesis of cardiovascular diseases.

Main Methods:

  • Literature review of recent studies on circRNAs and CVD.
  • Analysis of circRNA biogenesis pathways.
  • Synthesis of current knowledge on circRNA functions in cardiovascular health and disease.

Main Results:

  • CircRNAs exhibit unique circular structures and stable expression.
  • Specific circRNAs are implicated in various cardiovascular conditions.
  • CircRNAs can act as miRNA sponges or regulate gene expression.

Conclusions:

  • CircRNAs represent a promising area of research for understanding and potentially treating CVD.
  • Further investigation into circRNA mechanisms is warranted for therapeutic development.

Keywords:
BiosynthesisCardiovascular diseaseCircular RNAsDatabaseFunctions

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