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The relationship between calcific severe aortic stenosis and systemic immune-inflammation index

Mehmet Erdoğan1,2, Selçuk Öztürk3, Burak Kardeşler1

  • 1Department of Cardiology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|March 27, 2021
PubMed

Insights

The Systemic Immune-Inflammation Index (SII) can predict severe calcific aortic stenosis (AS). Higher SII levels correlate with AS severity, offering a new predictive marker for this common elderly valvular disease.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Calcific aortic stenosis (AS) is a prevalent valvular heart disease, particularly in the elderly.
  • Inflammation is a key factor in the pathophysiology of AS.
  • The Systemic Immune-Inflammation Index (SII), derived from neutrophil, lymphocyte, and platelet counts, is a novel inflammation marker.

Purpose of the Study:

  • To evaluate the predictive capability of SII in patients with severe calcific AS.
  • To explore the correlation between SII and hemodynamic parameters in AS.

Main Methods:

  • Patients with severe calcific AS were divided into High Flow-High Gradient (HFHG) and Low Flow-Low Gradient (LFLG) groups.
  • A control group without AS was included for comparison.
  • SII was calculated using the formula: (platelet count * neutrophil count) / lymphocyte count.

Main Results:

  • SII levels were significantly higher in both HFHG and LFLG AS groups compared to controls (P < .001).
  • SII showed a positive correlation with mean aortic transvalvular pressure gradient (r = .342, P < .001) and a negative correlation with Aortic Valve Area (AVA) (r = -.461, P < .001).
  • Multivariate analysis identified SII as an independent predictor of severe AS (OR: 1.004, 95% CI: 1.003-1.004), with high SII (>661) being a significant predictor (OR: 5.78, 95% CI: 3.93-4.89).

Conclusions:

  • The Systemic Immune-Inflammation Index (SII) is a valuable tool for predicting severe calcific AS.
  • SII levels are significantly associated with AS severity, correlating with key hemodynamic measures like AVA and pressure gradient.
Abstract

Keywords:
aortic stenosislymphocyteneutrophilsystemic immune-inflammation indextransthoracic echocardiography

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