Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia
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Updated: Nov 11, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Salah Aref1, Mohamed Al Agdar1, Ahmed Ramez2
1Hematology Unit, Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.
Objectives:
This study aimed to assess the prognostic value of cortactin and HS1 genes expression in adult B-cell acute lymphoblastic leukemia.
Methods:
The study included a cohort of 74 adult B-ALL patients and 76 controls. Cortactin and HS1 genes expression were quantified by real time PCR.
Results:
The expression of cortactin and HS1 were significantly higher in B-ALL patients at diagnosis as compared to post induction levels (p.
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