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Updated: Nov 11, 2025

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Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2020
Majken T Wingo1, Jill M Huber1, Jason H Szostek2
1Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn.
The American Journal of Medicine
|March 28, 2021
Summary
Staying current with medical research is hard. This study identified 7 key practice-changing articles in internal medicine, excluding COVID-19, to aid clinicians.
Area of Science:
- Internal Medicine
- Evidence-Based Practice
- Clinical Research Dissemination
Background:
- Keeping up with medical literature is challenging due to the rapid pace of research.
- Identifying practice-changing studies is crucial for updating clinical guidelines and patient care.
- Focusing on non-pandemic research highlights broader shifts in internal medicine.
Purpose of the Study:
- To identify significant practice-changing articles in general internal medicine.
- To provide clinicians with a curated list of high-impact research.
- To facilitate the integration of new evidence into outpatient clinical practice.
Main Methods:
- A systematic review of 7 high-impact internal medicine journals was conducted.
- Excluded Coronavirus disease-19 (COVID-19) research to focus on other areas.
- Utilized a modified Delphi method with 7 internists to select articles based on clinical relevance, practice impact, and evidence strength.
- Reviewed supplementary resources like American College of Physicians Journal Club and NEJM Journal Watch.
Main Results:
- Seven practice-changing articles relevant to outpatient general internal medicine were identified.
- Articles were selected based on their potential to modify clinical practice.
- Consensus was reached on the relevance, impact, and strength of evidence for the selected studies.
Conclusions:
- A curated selection of 7 practice-changing articles can help internists stay abreast of critical updates.
- This focused approach aids in disseminating essential research beyond the immediate pandemic context.
- The identified articles represent significant shifts in evidence-based medicine for general internal medicine practice.
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