Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2025

The continually evolving nature of evidence-based medicine requires clinicians to update their practice in response to new data. Integrating new research is essential for advancing clinical practice. To this aim, a panel of seven internists screened articles from seven high-impact internal medicine journals deemed most relevant to general outpatient care: New England Journal of Medicine, The Lancet, Annals of Internal Medicine, Journal of the American Medical Association (JAMA), JAMA Internal Medicine, British Medical Journal (BMJ), and Public Library of Science (PLoS) Medicine. The review also included curated summaries and evidence databases, including American College of Physicians Journal Club, NEJM Journal Watch, BMJ Evidence-Base Medicine, McMaster ACCESSSS/DynaMed Evidence Alerts, and Cochrane Reviews. Consensus was achieved using a modified Delphi process that emphasized outpatient relevance, impact on clinical practice, and overall quality of evidence. Related articles addressing the same clinical topics were evaluated together. Ultimately, seven practice-changing articles were included.