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Updated: Nov 11, 2025

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Plasma proteomic profile associated with platelet dysfunction after trauma.

Alexander St John1, Yi Wang2, Junmei Chen2

  • 1Department of Emergency Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Journal of Thrombosis and Haemostasis : JTH
|March 28, 2021
PubMed
Summary
This summary is machine-generated.

Platelet dysfunction after trauma is linked to specific changes in plasma proteins. Identifying these twelve key proteins offers new targets for treating bleeding complications in trauma patients.

Keywords:
blood platelet disordershemorrhagehemostasismultiple traumaproteomics

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Area of Science:

  • Trauma research
  • Proteomics
  • Hemostasis

Background:

  • Coagulopathic bleeding is a significant cause of mortality following trauma.
  • Platelet dysfunction is a contributing factor to this bleeding, but its causes are not well understood.
  • The plasma environment may hold clues to the pathways involved in platelet dysfunction.

Purpose of the Study:

  • To characterize the plasma proteomic profile changes associated with platelet dysfunction after trauma.
  • To identify specific proteins altered in trauma patients with impaired platelet function.

Main Methods:

  • Collected blood samples from 110 severely injured trauma patients.
  • Utilized untargeted proteomics (nanoflow liquid chromatography tandem mass spectrometry) on patient samples.
  • Compared proteomic profiles between patients with preserved and impaired platelet aggregation responses.

Main Results:

  • Identified twelve proteins with significantly different abundance levels between groups.
  • These proteins are involved in microvascular obstruction, platelet activation, immune activation, and protease activation.
  • Patients with platelet dysfunction had more severe injuries.

Conclusions:

  • This study describes proteomic profile changes linked to post-trauma platelet dysfunction.
  • Twelve proteins show the most significant alterations, highlighting potential targets for intervention.
  • Further investigation into these protein pathways is crucial for understanding and treating trauma-induced platelet dysfunction.