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Hormone Replacement Therapy and Development of New Asthma
Erik Soeren Halvard Hansen1, Kristian Aasbjerg2, Amalie Lykkemark Moeller3
1Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Chest
|March 29, 2021
Summary
Hormone replacement therapy (HRT) may increase the risk of new asthma diagnoses in women aged 40-65. Discontinuing HRT might also lead to stopping asthma treatment.
Area of Science:
- Reproductive endocrinology
- Pulmonology
- Pharmacoepidemiology
Background:
- Hormone replacement therapy (HRT) is widely used by women globally.
- Existing research presents conflicting evidence on HRT's effects on asthma, suggesting both protective and harmful impacts.
Purpose of the Study:
- To investigate the association between hormone replacement therapy (HRT) and the new development of asthma in menopausal women.
Main Methods:
- A nested case-control study utilized Danish health registers from 1995 to 2018.
- Asthma diagnosis was established by two inhaled corticosteroid prescriptions within two years.
- HRT was defined by two female sex hormone prescriptions within six months.
Main Results:
- Active HRT was associated with a 1.63-fold increased hazard of new asthma development in women aged 40-65.
- Women with asthma who stopped HRT were more likely to discontinue their asthma medication (HR 2.12).
Conclusions:
- Hormone replacement therapy appears to influence asthma development in mature women.
- Healthcare providers and patients should consider the potential for new respiratory symptoms and the option of HRT discontinuation.
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