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Published on: May 22, 2019
Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center
Lv Hong1, Wang Hongmei2, Xie Leijie3
1Clinical Diagnosis Department of Beijing Tiantan Hospital & Capital Medical University, China; NMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Fengtai district, Beijing, 100076, China; Beijing Engineering Research Center of Immunological Reagents Clinical Research, Fengtai district, Beijing, 100076, China.
Background And Aims:
The present study aims to correlate the severity of post-stroke depression (PSD) and serum ceramide concentration.
Materials And Methods:
In this two-center case-control study, we prospectively collected clinical and demographical information from age and gender-matched 51 PSD patients, 56 non-post-stroke depression (Non-PSD) patients, and 39 patients with major depression (MD) to perform the suitable biochemical analysis to bring a correlation in causing depression in patients soon after the stroke. The ROC curve method was used to evaluate ceramide's diagnostic efficacy in all three groups of patients. A follow-up analysis was also conducted based on PSD severity to associate serum ceramide levels and neuropsychiatric symptoms. The severity of the patient's depressive symptoms was assessed by using the self-rating depression scale (SDS).
Results:
In comparison between PSD and MD patients, three serum ceramide species were found to be significantly different. Compared with Non-PSD patients, PSD patients had significantly higher levels of all the four serum ceramides, and increasing levels ofC16:0, C18:0(VS MD) and C16: 0(VS Non-PSD) serve as a diagnostic tool and an independent risk factor in all three categories of patients. Moreover, the follow-up analysis results showed that, as the treatment progressed, the differences in the 3 serum ceramide species were statistically significant.
Conclusion:
There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research.
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