Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viral Mutations00:36

Viral Mutations

36.9K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
36.9K
What is Evolutionary History?02:35

What is Evolutionary History?

41.3K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
41.3K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

60.7K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
60.7K
Ecological Disturbance02:26

Ecological Disturbance

19.9K
An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced change in an ecosystem. The impact of an ecological disturbance, which can depend on its intensity, frequency, and spatial distribution, plays a significant role in shaping the species diversity within the ecosystem.
19.9K
Mutations in Microorganisms01:18

Mutations in Microorganisms

231
Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
231
Causality in Epidemiology01:21

Causality in Epidemiology

1.2K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Return on Returns: Building Scientific Capacity in AIDS Endemic Countries.

Health economics·2026
Same author

COVID-19 knowledge deconstruction and retrieval: an intelligent bibliometric solution.

Scientometrics·2023
Same author

One-year in: COVID-19 research at the international level in CORD-19 data.

PloS one·2022
Same author

International collaboration during the COVID-19 crisis: autumn 2020 developments.

Scientometrics·2021
Same author

Consolidation in a crisis: Patterns of international collaboration in early COVID-19 research.

PloS one·2020

Related Experiment Video

Updated: Nov 11, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

Topic evolution, disruption and resilience in early COVID-19 research.

Yi Zhang1, Xiaojing Cai2,3, Caroline V Fry4

  • 1Australian Artificial Intelligence Institute, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW 2007 Australia.

Scientometrics
|March 29, 2021
PubMed
Summary

The COVID-19 pandemic significantly disrupted coronavirus research, altering research topics and community cohesion. Epidemiology remained resilient, while Chinese researchers pioneered novel approaches.

Keywords:
COVID-19International collaboration.Research and developmentScienceTopic analysis

More Related Videos

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.2K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Related Experiment Videos

Last Updated: Nov 11, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.2K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.0K

Area of Science:

  • Virology
  • Epidemiology
  • Scientific Research Impact

Background:

  • The COVID-19 pandemic posed a significant challenge to the global scientific community.
  • Resilience theory provides a framework for understanding research community responses to crises.

Purpose of the Study:

  • To analyze the impact of the COVID-19 pandemic on the trajectory and community of coronavirus research.
  • To characterize changes in research topics and knowledge pathways.

Main Methods:

  • Extracted terms from early COVID-19 research articles.
  • Analyzed epistemic clusters and evolutionary pathways of knowledge.
  • Utilized statistical analysis to assess research community cohesion and topic shifts.

Main Results:

  • The pandemic substantially disrupted established coronavirus research lines.
  • Early COVID-19 research showed less cohesion compared to pre-pandemic research.
  • Epidemiology emerged as the most resilient research area.
  • Chinese researchers initiated novel research directions.

Conclusions:

  • The pandemic induced significant shifts in research focus and community structure.
  • The long-term impact on scientific progress and knowledge configuration remains uncertain.
  • Future research should investigate the sustainability of pandemic-induced research changes.