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Anna Fesser1, Marcel Kaiser1, Pascal Mäser1

  • 1Universität Basel Schweizerisches Tropen- und Public Health-Institut (Swiss TPH), Socinstraße 57, CH-4051 Basel, Schweiz.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|March 29, 2021
PubMed
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Correction: Mukavi et al. Antiprotozoal Aminosteroid Alkaloids from <i>Buxus obtusifolia</i> (Mildbr.) Hutch. <i>Molecules</i> 2025, <i>30</i>, 4558.

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Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
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Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
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Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
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Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
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Chagas disease, caused by Trypanosoma cruzi, requires new treatments, especially for the chronic stage. High-content imaging aids drug discovery by assessing antichagasic potential in cell culture assays.

Area of Science:

  • Parasitology
  • Infectious Diseases
  • Drug Discovery

Context:

  • Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
  • Transmission occurs via triatomine bugs, with global spread due to travel and migration.
  • There is an urgent need for novel therapeutics, particularly for chronic Chagas disease.

Purpose:

  • To highlight the contribution of high-content imaging in Chagas disease research.
  • To demonstrate the utility of fluorescent parasite assays in cell culture.
  • To assess the antichagasic potential of new drug candidates.

Summary:

  • High-content imaging facilitates the study of Trypanosoma cruzi.
  • Fluorescent parasite assays in cell culture enable determination of pharmacodynamic parameters.

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  • This approach aids in evaluating the efficacy of potential new drugs against Chagas disease.

    • Impact:

    • Accelerates the identification and development of new drugs for Chagas disease.
    • Improves the assessment of drug efficacy in preclinical stages.
    • Offers a valuable tool for combating a globally spreading neglected tropical disease.