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Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive

Pei Wang1, Fang Wang1,2,3,4, Lan Ni1

  • 1Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Acta Pharmaceutica Sinica. B
|March 29, 2021
PubMed
Abstract

Keywords:
AAMI, age-associated memory impairmentAD, Alzheimer's diseaseAMPARs, α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptorsCaMKII, Ca2+/calmodulin-dependent protein kinase IICognitive disorderDG, dentate gyrusDS, Down syndromeDTNB, 5,5-dithio-bis-2-nitrobenzoic acidDTT, dithiothreitolEPSPs, excitatory postsynaptic potentialsGSK-3β, glycogen synthase kinase-3βGlu, glutamateH2O2, hydrogen peroxideHFS, high-frequency stimulationHydrogen sulfideLFS, low-frequency stimulationLTD, long-term depressionLTP, long-term potentiationLearning and memoryLong-term potentiationMF, mossy fiberN-Methyl-d-aspartate receptorNAC, N-acetyl cysteineNADPH, nicotinamide adenine dinucleotide phosphateNMDARs, N-methyl-d-aspartate receptorsNO, nitric oxideOxidative stressPTM, posttranslational modificationROS, reactive oxygen speciesReactive oxygen speciesSC, Schaffer collateralSNOC, S-nitrosocysteineSynaptic plasticityTFAM, mitochondrial transcription factor AVD, vascular dementia

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