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Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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Related Experiment Video

Updated: Nov 11, 2025

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

Skeletal Muscle Regenerative Engineering.

Xiaoyan Tang^1,2,3,4, Leila Daneshmandi^1,2,3,5, Guleid Awale^1,2,3,6

¹Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, CT 06030, USA.

Regenerative Engineering and Translational Medicine

|March 29, 2021

Summary

This summary is machine-generated.

Skeletal muscle regeneration faces limitations with severe injuries. Regenerative engineering, combining biomaterials, stem cells, and physical forces, shows promise for enhancing muscle repair and function.

Keywords:

animal models biomaterials cell therapy skeletal muscle regeneration small molecules

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Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

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Last Updated: Nov 11, 2025

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Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

Area of Science:

Biomedical Engineering
Regenerative Medicine
Materials Science

Background:

Skeletal muscle has limited regeneration capacity after severe trauma or disease.
Severe injuries compromise the natural muscle healing process, necessitating advanced interventions.

Purpose of the Study:

To review recent advancements in skeletal muscle regenerative engineering.
To explore the convergence of biomaterials, stem cells, and physical forces for muscle regeneration.

Main Methods:

Investigating various biomaterials: nanofibers, hydrogels, scaffolds, decellularized tissues, conductive matrices.
Analyzing the interaction of biomaterials with cells via physical, chemical, and mechanical cues.
Reviewing physical stimulation strategies (mechanical, electrical) to improve muscle function.

Main Results:

Biomaterials modulate cell behavior, promoting skeletal muscle regeneration.
Physical forces enhance muscle contractility and functionality.
Animal models for volumetric muscle loss and rotator cuff injury are discussed.

Conclusions:

The convergence of advanced biomaterials, stem cells, and physical forces offers promising strategies for skeletal muscle regeneration.
Integrating insights from developmental biology, immunology, and genetics is crucial for clinical translation.
Regenerative engineering holds significant potential for treating debilitating muscle injuries.