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Comparative analysis of mutational hotspots in the spike protein of SARS-CoV-2 isolates from different geographic

Sanghoo Lee1, Mi-Kyeong Lee2, Hyeongkyun Na1

  • 1Center for Companion Biomarker, Seoul Clinical Laboratories (SCL) Healthcare Inc., Republic of Korea.

Gene Reports
|March 29, 2021
PubMed

Keywords:
ACE2, angiotensin-converting enzyme-2COVID-19, Coronavirus diseaseCT, cycle thresholdD614G mutationDifferent geographic originsE, envelopeM, membraneMutational hotspotsN, nucleocapsidNGS, next-generation sequencingNsp3, nonstructural proteinOrf, open reading frameRDB, receptor-binding domainRT-qPCR, reverse transcriptase-quantitative polymerase chain reactionRdRp, RNA-dependent RNA polymeraseS, SpikeSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2Spike geneSpike proteinTMPRSS2, transmembrane serine protease2

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