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Updated: Nov 11, 2025

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
Published on: May 19, 2016
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
Jing Li1, Go Urabe1, Yitao Huang1
1Department of Surgery, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Abstract:
Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4's phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis.
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