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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

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Hypertrophic Cardiomyopathy Is Associated with Altered Left Ventricular 3D Blood Flow Dynamics

Judith T Pruijssen1, Bradley D Allen1, Alex J Barker1

  • 1Department of Biomedical Engineering and Physics (J.T.P.) and Department of Radiology & Nuclear Medicine (P.v.O.), Academic Medical Center, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands; Department of Radiology (B.D.A., J.C.C., M.M.), Department of Medicine-Cardiology (R.O.B., L.C.), and Department of Biomedical Engineering (M.M.), Northwestern University, Chicago, Ill; and Department of Radiology & Bioengineering, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Denver, Colo (A.J.B.).

Radiology. Cardiothoracic Imaging
|March 29, 2021
PubMed

Insights

Four-dimensional flow MRI quantifies elevated velocity volumes (EVV) in hypertrophic cardiomyopathy (HCM) patients, revealing associations with systolic anterior motion (SAM) and mitral regurgitation (MR). This technique offers insights into HCM

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Medical Physics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex heart muscle disease.
  • Understanding the hemodynamic alterations in HCM is crucial for patient management.
  • Systolic anterior motion (SAM) and mitral regurgitation (MR) are common complications in HCM.

Purpose of the Study:

  • To investigate the association between hemodynamic parameters and clinical manifestations in HCM using 4D flow MRI.
  • To quantify elevated velocity volumes (EVV) in the left ventricle (LV) of HCM patients.
  • To correlate EVV with SAM, MR, stroke volume, and cardiac mass.

Main Methods:

  • 13 patients with HCM and 11 healthy controls underwent 4D flow MRI.
  • Left ventricular (LV) velocity maps were analyzed to calculate EVV.
  • Standard cine imaging assessed SAM, MR, stroke volume, and cardiac mass.

Main Results:

  • Systolic EVV in HCM patients was significantly associated with elevated aortic peak velocity, decreased LV outflow tract diameter, and increased cardiac mass.
  • EVV was significantly higher in patients with SAM and MR compared to those without.
  • Diastolic LV velocity correlated with septal thickness.

Conclusions:

  • Quantification and visualization of EVV in the LV are feasible using 4D flow MRI.
  • EVV may provide valuable insights into the altered hemodynamics and clinical manifestations of HCM.
  • 4D flow MRI is a promising tool for evaluating HCM patients.
Abstract

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