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Coronavirus Disease 2019: Initial Detection on Chest CT in a Retrospective Multicenter Study of 103 Chinese Patients

Zeying Wen1, Yonge Chi1, Liang Zhang1

  • 1Department of Radiology, The First Affiliated Hospital of Henan University of CM, 19 Renmin Road, Zhengzhou 450000, Henan Province, China (Z.W., J.C., L.C., D.W.); Department of Radiology, The Fifth Hospital of Anyang, Anyang, China (Y.C.); Department of Radiology, Zhumadian Central Hospital, Zhumadian, China (L.Z.); GE Healthcare, Shanghai, China (H.L.); Department of Radiology, XinYang Central Hospital, Xinyang, China (K.D.); and Department of Radiology, Xinxian People's Hospital, Xinxin, China (Z.L.).

Radiology. Cardiothoracic Imaging
|March 29, 2021
PubMed

Insights

Chest CT scans show high sensitivity for initial detection of coronavirus disease 2019 (COVID-19) in suspected patients. However, the modest negative predictive value indicates CT is not a reliable screening tool for COVID-19.

Area of Science:

  • Radiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) emerged as a global health crisis.
  • Accurate and timely diagnosis is crucial for patient management and disease control.
  • Chest computed tomography (CT) is frequently used for initial assessment of patients with suspected COVID-19.

Purpose of the Study:

  • To evaluate the diagnostic performance of chest CT scans in patients initially suspected of having COVID-19.
  • To determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of chest CT for COVID-19 detection.

Main Methods:

  • Retrospective analysis of data from 103 patients investigated for COVID-19.
  • All patients underwent chest CT and reverse-transcription polymerase chain reaction (RT-PCR) testing.
  • Performance metrics (sensitivity, specificity, PPV, NPV) were calculated for chest CT.

Main Results:

  • 85% of patients were confirmed to have COVID-19 by RT-PCR.
  • Chest CT demonstrated high overall sensitivity (93%) and PPV (92%).
  • The specificity (53%) and NPV (42%) of chest CT were modest, indicating potential for false negatives and positives.

Conclusions:

  • Initial chest CT scans exhibit high sensitivity for detecting COVID-19 in suspected cases.
  • The moderate NPV suggests chest CT alone is insufficient as a primary screening tool.
  • RT-PCR testing remains essential for definitive COVID-19 diagnosis.
Abstract

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