Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

5.2K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
5.2K
Proteomics01:33

Proteomics

8.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.8K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

249
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
249
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

62
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
62
Glomerular Filtration01:15

Glomerular Filtration

3.5K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
3.5K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

185
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
185

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-Acute Sequelae of COVID-19 (PASC) in Hospitalized and Ambulatory Patients: A Comparative Study.

Journal of clinical medicine·2026
Same author

Fibromuscular Dysplasia: Emerging Concepts Beyond the International Consensus.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Association of Urinary Complement Peptides with Kidney Function and Progression of Kidney Disease.

International journal of molecular sciences·2026
Same author

In silico prediction of optimal multifactorial intervention in chronic kidney disease.

Journal of translational medicine·2025
Same author

Omics-Mediated Treatment for Advanced Prostate Cancer: Moving Towards Precision Oncology.

International journal of molecular sciences·2025
Same author

A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations.

International journal of molecular sciences·2025
Same journal

Unveiling the post translational modification code in Alzheimer's pathogenesis: crosstalk between phosphorylation and acetylation.

Expert review of proteomics·2026
Same journal

Plasma proteome profiles of standard-risk and high-risk childhood acute lymphoblastic leukemia.

Expert review of proteomics·2026
Same journal

Potential proteomic biomarkers for monitoring clinical studies in Duchenne/Becker muscular dystrophy.

Expert review of proteomics·2026
Same journal

Proteomics-based approaches to neutrophil biology.

Expert review of proteomics·2026
Same journal

Deciphering mitochondrial metabolic vulnerabilities in ovarian clear cell carcinoma with mass spectrometry-based clinical proteomics.

Expert review of proteomics·2026
Same journal

The proteomic origin of the genetic code.

Expert review of proteomics·2026
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

422

Understanding glomerular diseases through proteomics.

E Mavrogeorgis1, H Mischak1,2, J Beige3,4

  • 1Mosaiques Diagnostics GmbH, Hannover, Germany.

Expert Review of Proteomics
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

Proteomics analysis reveals novel biomarkers for chronic kidney disease (CKD). Understanding these molecular patterns in bio-fluids and tissues offers new insights for improved CKD management and personalized medicine approaches.

Keywords:
BiomarkerCKD273bloodchronic kidney diseaseclinical proteomicstissueurine

More Related Videos

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.2K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Related Experiment Videos

Last Updated: Nov 11, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

422
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.2K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • Chronic kidney disease (CKD) is a prevalent and complex condition.
  • Understanding CKD pathology at a molecular level is crucial for better patient outcomes.
  • Proteomics offers a promising avenue for biomarker discovery in CKD.

Purpose of the Study:

  • To review recent proteomics biomarkers for CKD.
  • To provide insights into CKD pathology through proteomic analysis.
  • To explore the application of proteome analysis in CKD research.

Main Methods:

  • Systematic review of recent literature (last 5 years) on CKD proteomics.
  • Analysis of proteins and peptides from various biological sources (urine, blood, tissue).
  • Identification of associated biological pathways.

Main Results:

  • Identification of numerous proteins and peptides linked to CKD.
  • Association of these biomarkers with various biological pathways.
  • Demonstration of proteomics' potential in uncovering CKD molecular mechanisms.

Conclusions:

  • A comprehensive understanding of CKD pathology via proteomics is essential for effective management.
  • Clinical proteomics has yielded promising initial findings for CKD.
  • Integrating proteomic insights with personalized medicine could significantly advance CKD care.