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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

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Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
173
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

155
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
155
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

114
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
114
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

159
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Related Experiment Video

Updated: Nov 11, 2025

Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
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Hemodynamic Changes in an Actively Rupturing Abdominal Aortic Aneurysm.

Davis B McClarty1, David C S Kuhn1, April J Boyd2

  • 1Department of Mechanical Engineering, University of Manitoba, Winnipeg, Manitoba, Canada.

Journal of Vascular Research
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

Computational fluid dynamics reveal significant hemodynamic and structural changes precede abdominal aortic aneurysm (AAA) rupture. These findings in AAA rupture dynamics may improve risk prediction algorithms.

Keywords:
Abdominal aortic aneurysmAortic ruptureHemodynamicsIntraluminal thrombus

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A New Murine Model of Endovascular Aortic Aneurysm Repair
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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Imaging Analysis

Background:

  • Abdominal aortic aneurysms (AAAs) pose a significant rupture risk.
  • Predicting AAA rupture remains a clinical challenge.
  • Understanding the biomechanics of AAA rupture is crucial for improved patient outcomes.

Purpose of the Study:

  • To investigate the hemodynamic and structural changes in an actively rupturing AAA over a 9-day period using computational fluid dynamics (CFD).
  • To identify precursor events to AAA rupture.
  • To assess the role of intraluminal thrombus (ILT) and wall shear stress in AAA rupture.

Main Methods:

  • Computational fluid dynamics (CFD) simulations were employed.
  • Analysis of hemodynamic changes, including wall shear stress and flow velocity.
  • Tracking of contrast migration into the intraluminal thrombus (ILT) and adventitial layer.

Main Results:

  • Active contrast migration into the ILT was observed, culminating in adventitial breach.
  • A discrete disruption of adventitial calcium with bleb formation preceded rupture.
  • Rupture occurred in a low wall shear stress region, with a marked increase in AAA diameter (6.6 to 8.4 cm) and luminal area (6.28 to 12.08 cm2).
  • Increased luminal area and altered flow velocity within the ILT preceded significant AAA diameter increase.

Conclusions:

  • Significant hemodynamic and structural changes occur in the AAA flow lumen before substantial aortic diameter increase or rupture.
  • AAA rupture may occur at smaller diameters than currently measured.
  • These findings have critical implications for developing more accurate AAA rupture risk prediction algorithms.