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Engineering Advances in Spray Drying for Pharmaceuticals.

John M Baumann1, Molly S Adam1, Joel D Wood1

  • 1Small Molecules, Lonza Pharma & Biotech, Bend, Oregon 97701, USA; email: john.baumann@lonza.com, molly.adam@lonza.com, joel.wood@lonza.com.

Annual Review of Chemical and Biomolecular Engineering
|March 30, 2021
PubMed
Summary
This summary is machine-generated.

Spray drying is a key pharmaceutical technology for creating amorphous solid dispersions and improving drug delivery. Advances enable robust product development for oral and biologic applications, with future opportunities in dry powder formulations.

Keywords:
amorphous solid dispersionsbiologicsinhalationparticle engineeringscale-upspray drying

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Drug Delivery Systems

Background:

  • Spray drying is a widely adopted technology in chemical and food industries, now significantly impacting pharmaceuticals.
  • Amorphous solid dispersions represent a major and expanding drug delivery strategy.
  • Maturing spray drying technology allows for robust product development addressing diverse pharmaceutical challenges.

Purpose of the Study:

  • To review engineering advances in spray drying for pharmaceutical applications.
  • To provide an in-depth view of spray drying for amorphous solid dispersions.
  • To highlight current and emerging applications of spray drying in the pharmaceutical industry.

Main Methods:

  • Review of engineering advancements in spray drying technology.
  • Analysis of significant pharmaceutical applications, focusing on amorphous solid dispersions.
  • Examination of process parameters and their impact on product quality attributes.

Main Results:

  • Enhanced understanding of spray drying parameters facilitates robust pharmaceutical product development.
  • Spray drying is successfully used for approved small-molecule oral products.
  • Emerging applications include the delivery of biologics and non-oral dry powder formulations.

Conclusions:

  • Spray drying offers significant opportunities for pharmaceutical innovation, particularly in drug delivery.
  • Continued advancements in formulation and process optimization are driving wider adoption.
  • The technology is poised for substantial future growth within the pharmaceutical sector.