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A systematic review exploring the bidirectional relationship between puberty and autoimmune rheumatic diseases
Nina M de Gruijter1,2, Meena Naja1, Hannah Peckham1
1Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London, Rayne Building, London, W1CE 6JF, UK.
Pediatric Rheumatology Online Journal
|March 30, 2021
Summary
Puberty significantly impacts autoimmune rheumatic diseases (ARDs), often causing delayed development and hormonal issues in patients. Further research is needed to understand this complex bidirectional relationship between puberty and ARDs.
Area of Science:
- Rheumatology
- Endocrinology
- Pediatrics
Background:
- Autoimmune rheumatic diseases (ARDs) exhibit a notable sex bias, particularly after puberty.
- The interplay between pubertal development and ARDs requires further investigation.
Purpose of the Study:
- To systematically review and elucidate the bidirectional relationship between puberty and autoimmune rheumatic disease outcomes.
- To identify research gaps concerning puberty and ARD interactions.
Main Methods:
- Systematic search of endocrinology and rheumatology literature up to October 2019.
- Extraction of data on study design, demographics, and outcome measures.
- Methodological quality assessment using the Newcastle-Ottawa Scale (NOS).
Main Results:
- Sixteen non-randomized studies were identified, examining puberty's impact on ARDs and vice versa.
- Common findings include delayed puberty, hormonal abnormalities, and reduced height/weight in juvenile idiopathic arthritis (JIA) and juvenile systemic lupus erythematosus (JSLE) patients.
- Earlier onset of JSLE correlated with increased disease severity and treatment needs.
Conclusions:
- A bidirectional relationship between puberty and ARDs is evident.
- Further high-quality research is essential to fully understand this complex interaction.
- Implementing puberty-related clinical assessments in ARD patients is recommended to improve outcomes and guide future studies.
Keywords:
AdolescenceAutoimmune rheumatic diseasesJuvenile idiopathic arthritisPubertySex hormonesSystemic lupus erythematosusMore Related Videos
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