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Synthetic Approaches to the New Drugs Approved during 2019
Andrew C Flick1, Carolyn A Leverett2, Hong X Ding3
1Takeda Pharmaceuticals, 9625 Towne Centre Drive, San Diego, California 92121, United States.
Abstract:
New drugs introduced to the market are privileged structures having affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody-drug conjugates, provide insight into molecular recognition and simultaneously function as leads for the design of future medicines. This review is part of a continuing series presenting the most likely process-scale synthetic approaches to 40 NCEs approved for the first time anywhere in the world in 2019.
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