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Cell-type-specific binocular vision guides predation in mice.

Keith P Johnson1, Michael J Fitzpatrick2, Lei Zhao3

  • 1John F. Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.

Neuron
|March 30, 2021
PubMed
Summary
This summary is machine-generated.

Mice use binocular vision for hunting, relying on specific retinal ganglion cells (RGCs) that project to ipsilateral brain areas. Disrupting these cells significantly impairs predatory success in mice.

Keywords:
depth perceptionganglion cellhuntingipsilateral projectionprey captureretinastereopsis

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Area of Science:

  • Neuroscience
  • Vision Science
  • Evolutionary Biology

Background:

  • Predation is a key evolutionary driver, with vision being crucial for hunting success.
  • The specific adaptations of visual systems and viewing strategies for predation remain incompletely understood.
  • Mammalian binocular vision depends on retinal ganglion cell (RGC) projections to both ipsilateral and contralateral brain hemispheres.

Purpose of the Study:

  • To investigate how viewing strategies and visual systems are adapted for predation in mice.
  • To identify the role of specific RGCs, particularly those projecting ipsilaterally (ipsi-RGCs), in mammalian hunting behavior.
  • To understand the cellular and systems-level mechanisms supporting binocular vision in predatory contexts.

Main Methods:

  • 3D tracking of predator-prey interactions between mice and crickets.
  • Large-scale single-cell recordings and morphological reconstructions of mouse retinal ganglion cells (RGCs).
  • Selective ablation of ipsi-RGCs in adult mice to assess the impact on hunting success.
  • Presentation of prey-based stimuli to evaluate RGC function.

Main Results:

  • Mice utilize their binocular visual fields to track prey, and monocular vision severely compromises hunting ability.
  • A small subset of RGC types (9 of 40+) in the ventrotemporal retina project to ipsilateral brain targets (ipsi-RGCs).
  • Selective elimination of ipsi-RGCs (<2% of total RGCs) led to a significant decrease in mouse hunting success.
  • Specific ipsi-RGC types were identified as crucial for reliably signaling prey presence.

Conclusions:

  • Viewing strategies in mice are tightly linked to a spatially restricted and cell-type-specific population of ipsi-RGCs.
  • These ipsi-RGCs are essential for supporting the binocular vision required for effective predation.
  • The findings highlight a specialized neural circuit for vision-guided hunting in mammals.